Faculty

Membrane protein crystallography; structural determination of membrane transport proteins

How does the brain control fear and anxiety elicited by different imminent threats?

Cardiac Neurobiology, Bioinformatics, Transgenic murine and Porcine Models of Cardiovascular disease, Viral Tracing, Neuromodulation

How does neuronal activity during development affect synapse and circuit assembly?

Molecular mechanisms of cardiovascular development

Autonomic control of the normal and diseased heart

We study the sex chromosomal and hormonal factors that cause sex differences in physiology and disease.

Mitochondria, bioenergetics and electrophysiology

Neurobiology of circadian rhythms

Role of bone morphogenetic proteins in vascular disease

Neurochemical and anatomical pathways in the vertebrate retina that mediate vision

Molecular mechanistic and translational studies of cardiorespiratory diseases

Ion channel disorders of skeletal muscle, mathematical modeling, gene therapy

Neural repair after stroke

Neuronal mechanisms controlling jaw movement

Neural control of behavior, circadian rhythms

Effects of sex variables on the neural control of temperature and energy balance

We investigate immuno-metabolic dysregulation in macrophages during aging, metabolic disease, and cancer

Muscle regeneration, muscular dystrophy, drug discovery, mouse models of disease

Neuron-glial interactions in health and disease

Cardiac repair and regeneration, wound healing, progenitors, fibroblasts

Computational modeling of gene regulation, cell signaling and cellular physiology

We are uncovering the mechanisms of cardiovascular calcification and how it is increased by statins and exercise.

mPFC circuits for learning and memory

Survival and quality-of-life benefit offered by heart transplantation, mechanical circulatory support and other treatment options

Control of cell physiology by mitochondrial metabolism and bioenergetics

Sleep regulation and function

Lymphocyte development from embryogenesis through senescence

Neural control of movement and neuromuscular plasticity

Heart disease, pulmonary hypertension and sex differences in cardiopulmonary disease

My laboratory investigates the physiology of mammalian photoreceptors.

Neural circuit neurophysiology and behavior

Systemic iron metabolism and host defense

Mathematical modeling of electrophysiology

Mechanobiology of vascular inflammation and degeneration in eye diseases

The focus of my laboratory's research is on the cell biology of memory, particularly how memories are stored.

Action of diet and exercise on brain injury and disease

Mechanisms of membrane transport, channels, homeostasis, cryoEM structural biology MIcroED

Cancer and Immuno Systems Biology

Synaptic function

neurodegeneration and regeneration, aging, mitochondria

Molecular mechanism of innate and adaptive immunity

The neural basis of sensory behaviors in free-living and parasitic nematodes

Neural mechanisms underlying sleep state

Molecular underpinnings of insulin resistance and the relationships between insulin resistance, obesity and chronic disease

Neural circuit mechanism of animal social behavior

Our multidisciplinary research team focuses on address tissue/organ development, injury, and repair by embracing advanced imaging, computation, molecular, and senor technology.

Microbiome, Neurobiology of Disease, Neuroimmunology, Host-Microbe Interactions

Molecular mechanisms of aging and longevity regulation

My laboratory studies host-microbiome interactions in gastrointestinal, metabolic, and inflammatory disorders.

Therapeutic approaches for alzheimer's disease

We are interested in how glia regulate neural circuits.

Characterizing adipose tissue biology, especially reveals in genetic factors controlling fat tissue behavior, which influences energy homeostasis, metabolic processes, and the development of obesity

We study molecular and cellular mechanisms of autism, glioma and motor neuron repair.

Nutrient, microbiome and metabolism

Mitochondria in metabolic diseases

Photoreceptors and plant development

Neuronal circuits in the spinal cord involved in autonomic and volitional motor functions and modeling clinical interventions that treat spinal cord injury to describe physiological effects and cellular mechanisms of functional recovery.

Our lab uses genetic approaches, in human subjects and animal models, to investigate interactions involved in common forms of cardiovascular disease.

cardiovascular function, extracellular vehicles as therapeutic agents, biopacemakers

Neural mechanisms of motor control and learning.

Neurobiology of stress and visceral pain

Systems and computational neuroscience

Sensory processing/motor control, especially auditory feedback control of vocalization; Behavioral Neuroscience (Neuroethology)

Neurosteroid regulation of reproduction

Mechanisms of cardiovascular risks from tobacco products, especially electronic cigarette vapingng

How obesity increases cancer incidence and makes cancer harder to cure, specifically childhood leukemia

Developmental mechanism of congenital heart disease

Auditory behavior, neurophysiology and mechanics

Iron physiology and pathology: mechanisms and regulatory circuits (pregnancy, inflammation, infection, iron deficiency and iron overload)

Synaptic and Molecular Mechanisms Underlying Memory Formation

Ion Channel Molecular Physiology and Biophysics

Chemotherapy-induced cardiac injury and repair; characterization of high-risk atherosclerotic lesions

The structure, function, and biogenesis of voltage dependent ion channels

Sleep and circadian regulatory mechanisms.

Molecular mechanisms of the progression and diversity of neurodegenerative diseases

Genetic Dissection of Retinal Circuits

Determine how transplanted olfactory ensheathing cells enhance axon regeneration after spinal cord injury

My research program focuses on developing integrative omics and data science approaches to elucidate the molecular mechanisms underlying physiological functions in normal and diseased hearts.

Molecular Physiology of Gastrointestinal Hormones

Investigating the mechanisms by which sleep traits serve learning and memory consolidation

Circuit dysfunction underlying atypical sensory processing in autism

The role of neuropeptides and hormones in disease states

Aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy

Mathematical modeling of cardiac arrhythmias, cardiac metabolism, protein-protein interaction dynamics, and signal transduction

Cardiovascular development and disease

Retina & Retinal Pigment Epithelium Biochemistry: Understanding Pathophysiology of Age-Related Macular Degeneration and related retinopathies using preclinical models

Physiology and pathology of non-coding RNA and their interactors in hematopoiesis

Lipoproteins and lipid metabolism in human diseases

The Reed lab studies mechanisms of immune-mediated allograft injury and mapping innate and adaptive immune responses to viral and bacterial pathogens.

Genetics of obesity and diabetes

Mechanobiology, Mechanotransduction

Noncoding RNA, RNA modification, metabolism and heart disease

My laboratory is interested in elucidating the mechanism of phototransduction in retinal rods and cones, and establishing how the information generated by these photoreceptors is encoded downstream in the retina.

Steroid hormone synthesis and action in birds; hormonal control of brain and behavior in tropical bird species

Dynamic regulation of neurotransmitter release

Synaptogenesis, neural circuit development, and the determinants of whole brain dynamics

Mitochondria & metabolism in CVD models; adipose tissue bionergetics

Autonomic regulation of cardiac excitability

Interactions between different immune cells, including dendritic cells, T cells, and B cells, in the pathogenesis of autoimmune diseases, with a current focus on cellular migration, immune tolerance induction, and immune modulation

Muscular dystrophy, gene therapy, CRISPR based therapies for DMD and immune response to AAV vectors

Neuropharmacology

Novel signaling pathways that suppress pathogenic blood vessels

Brain-gut interaction

Immunometabolism - lipid metabolism and immunity

The immunobiology and physiology of muscle disease, regeneration and development

Metabolism, gene regulation, diabetes, atherosclerosis

Neural circuit development, understanding cortical plasticity from synapses to circuits

Mechanisms of inherited photoreceptor degenerations

Pulmonary vascular biology, Right heart dysfunction, Cardiopulmonary pathophysiology, Cardioprotection

Gene regulation, nutrition and metabolic diseases

Understanding the role of the nervous system in promoting cardiac arrhythmias in setting of heart disease using a combination of tissue clearing, optogenetic, neural recordings, and electrical mapping techniques in small and large animal models to find and develop novel neuromdulatory therapies

Biophysics of muscle excitation-contraction coupling

Our lab is interested in understanding how cells regulate their metabolic programs. These studies will provide opportunities to understand how cells burn energy and how we may use that information to prevent obesity and treat diabetes

Chromatin biology and epigenomics of the cardiovascular system

Neurodegeneration in aging, cognitive decline, multiple sclerosis

Molecular biology of aging

Adult stem cells, bone regeneration and aging

Genomics and Signaling in Cardiometabolic Regulation and Therapies

Single Molecule Biophysics

Neural basisi for socially-learned vocal communication

systems biology, cellular signaling variability, spatial transcriptomics

Structure and function of cotransporters

Bioinformatics, genomics, neuroscience

Multitissue multiomics systems biology of complex diseases

I work on basic mechanisms for plasma triglyceride metabolism as well as diseases of the nuclear envelope.

Glia cell development and function in health and disease

Therapeutic development in ophthalmology

Molecular mechanisms regulating neuronal circuit assembly