Alan Grinnell
Research Interests:
Specific Preparations and On-going Projects: a. Using Xenopus nerve-muscle cell cultures, we are studying the properties of synapses. Patch electrode recordings can be made simultaneously from presynaptic varicosities and postsynaptic muscle cells, while reagents can be introduced intracellularly through another electrode on the neuronal cell body. This allows correlation of ionic currents with transmitter release and modulation of release, and analysis of molecular mechanisms of release. b. Using mature frog neuromuscular preparations, we are studying the mechanisms of regulation of transmitter release efficacy by muscle stretch and hyperosmolarity. Both involve presynaptic integrins, tension on which increases either intraterminal calcium or sensitivity to calcium. c. Another project is aimed at understanding the destabilization of ACh receptors in denervated endplates as a nerve reinnervates part of the junction. In addition, I have a long-standing interest in the echolocation capabilities of bats and neural correlates of echolocation.
Publications:
Kalko, E.K.V., Schnitzler, H.-U., Kaipf, I & Grinnell, A.D. (1998). Hunting and echolocation behavior in Noctilio albiventris: the evolution of piscivory Behavioral Ecology and Sociobiology 45: 305-319
Yazejian, B., DiGregorio, D., Vergara, J.L., Poage, R., Meriney, S.D. and Grinnell, A.D. (1997). Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses J. Neuroscience 17: 2990-3001
Chen, B.M and Grinnell, A.D. (1997). Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor nerve terminals J. Neuroscience 17: 904-916
Harada, Y. and A.D. Grinnell (1996). Regeneration of specific innervation in the Xenopus pectoralis muscle J. Neurobiol 31: 433-448
Grinnell, A. D & Harada, Y. (1996). Specificity and development of the innervation pattern of the Xenopus pectoralis muscle J. Neurobiol 31: 415-432
Grinnell, A.D (1995). Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions Physiol. Reviews 75: 789-834
Chen, B.M. and Grinnell, A.D. (1995). Integrins help mediate the stretch-induced modulation of transmitter release from frog motor nerve terminals Science 269: 1578-1580
Arnold, Arthur
Barnard, Jim
Berliner, Judith
Bostrom, Kristina
Bowie, James
Brent, Gregory
Cai, Hua Linda
Chandler, Scott
Chen, Fabian
Chou, Tom
Colwell, Christopher
Crosbie, Rachelle
Delot, Emmanuele
Demer, Linda
Devaskar, Sherin
Diamond, Jared
Edgerton, Reggie
Eghbali, Mansoureh
Eisenberg, David
Fain, Gordon
Frye, Mark
Garfinkel, Alan
Gelbart, William
Glanzman, David
Goldhaber, Joshua
Gomez-Pinilla, Fernando
Grinnell, Alan
Guo, Ming
Gwack, Yousang
Homsher, Earl
Hubbell, Wayne
Iruela-Arispe, Luisa
Kaback, Howard
Khakh, Baljit
Krasne, Sally
Maclellan, William
Mayer, Emeran
McCabe, Edward
Metzner, Walter
Middlekauff, Holly
Mody, Istvan
Narins, Peter
O'dell, Thomas
Olcese, Riccardo
Otis, Thomas
Papazian, Diane
Phelps, Patricia
Philipson, Kenneth
Ping, Peipei
Reisler, Emil
Sachs, George
Schlinger, Barnett
Schweizer, Felix
Scremin, Oscar
Simmons, Dwayne
Smith, Judith
Spencer, Melissa
Stefani, Enrico
Sun, Hui
Sun, Yi
Tidball, James
Tormey, John
Vergara, Julio
Vondriska, Thomas
Voskuhl, Rhonda
Walker, David William
Wang, Yibin
Watson, Andrew
Wayne, Nancy
Weiss, James
Weiss, Shimon
White, Stephanie
Wright, Ernest
Wu, Lily
Xiao, Grace
Xie, Cui-Wei (Tracy)
Zampighi, Guido
Zimmer, Richard